Florentino Ariza is a hopeless romantic who falls passionately for the beautiful Fermina Daza, but finds his love tragically rejected. Instead Fermina marriesdistinguished doctor Juvenal Urbino, while Florentino can only wait silently for her.

He can never forget his first and only true love. Then, fifty-one years, nine months and four days later, Fermina's husband dies unexpectedly. At last Florentino has another chance to declare his feelings and discover if a passion that has endured for half a century will remain unrequited, in a rich, fantastical and humane celebration of love in all its many forms.